AOP-DB SPARQL Endpoint

This service is a Virtuoso SPARQL endpoint that is loaded with RDF of the EPA Adverse Outcome Pathway Database (AOP-DB) from the US EPA, who won the implementation challenge. The AOP-DB is currently an internal EPA SQL database that supports discovery and development of putative and potential AOPs. The AOP-DB aggregates relationships between AOP-gene targets, chemical, disease, tissue, pathway, species orthology information, ontologies and gene interactions to characterise the impacts of chemicals on human health and the environment. The AOP-DB serves as a hypothesis generation and decision support tool for case study development. Associations are sourced from public annotation to provide biological context and are integrated with AOP information centralised in the AOP-Wiki. The AOP-DB allows for fast, automatic AOP profiling and exploration that gives a broad, systems-level overview of the biological context of AOPs, thus dramatically expediting predictive toxicology efforts. The long-term significance and impact of the AOP-DB tool is the continued translation of AOP biological context, and the ability to associate these data between and across AOPs, and with assay, chemical, and disease endpoints.