Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Predictive Toxicology and Risk Assessment

OpenRiskNet is a 3 year project with the main objective to develop an open e-Infrastructure providing resources and services to a variety of communities requiring risk assessment, including chemicals, cosmetic ingredients, therapeutic agents and nanomaterials. OpenRiskNet is working with a network of partners, organized within an Associated Partners Programme.

The e-Infrastructure

The main concept of the OpenRiskNet infrastructure are virtual research environments (VRE) integrating data, analysis, modelling and simulation services for all areas of risk assessment, which can be deployed to workstations as well as public and in-house cloud infrastructures.

Try it out

Feel free to test out one or multiple of the available services.

The Service Catalogue →

  • To get familiar with the OpenRiskNet concept, consult our case studies.
  • Try our workflows that can be directly applied or used as examples for further adaptations.

Tutorials and feedback

  • Webinars – Watch the recordings of the webinars introducing the infrastructure.
  • Help desk – Report issues, give feedback and browse our knowledge base.

You will need to login to access some of the services. Please check the login instructions, terms of use and privacy policy for details.

Resources for end-users

For scientists and members of academia, industry or regulatory agencies who would like to use the infrastructure for their predictive toxicology and risk assessment tasks.

More →

Resources for developers

For service developers, infrastructure providers or data managers who would like to integrate their databases and software tools into the OpenRiskNet infrastructure.

More →
More →

OpenRiskNet Services

In progress
The eNanoMapper prototype database is part of the computational infrastructure for toxicological data management of engineered nanomaterials, developed within the EU FP7 eNanoMapper project. Provides support for upload, search and ...

Provided by:
Maastricht University
Type:
Database / data source
Applicability domain:
Toxicology, Bioinformatics
Topic:
Chemical properties, Nano safety, Information extraction
For end-users
For developers
In progress
Predict ADME/PK with Confidence
The service predicts 8 basic human clinical ADME/PK-parameters directly from molecular structure and can also be used to optimize ADME/PK-characteristics of drug candidates.

Provided by:
Prosilico
Type:
Application, Software, Service
Applicability domain:
Predictive toxicology
Topic:
Kinetics, Structure-activity relationship (SAR / QSAR), Predictive modelling
Biological area:
Toxicokinetics
For end-users
Integrated
Collection of toxicological data sources exposed via OpenTox
Three of the most popular toxicologic open data sources are already publically available: the EPA's in vitro ToxCast/Tox21 database, the EPA's in vivo ToxRefDB database and the NIBIOHN's toxicogenomics Open ...

Provided by:
Edelweiss Connect
Type:
Database / data source, Application, Service
Applicability domain:
Computational modelling, Toxicology, Bioinformatics, Predictive toxicology
Topic:
Chemical properties, Risk assessment
Biological area:
Omics, NOAEL/LOAEL, Acute toxicity
For end-users
Integrated
Combining site-of-metabolism and reactivity for (P450) site-of-metabolism prediction. Includes structure-based predictor (from OpenRiskNet partner VU) and third-party (University of Copenhagen) reactivity predictor (SMARTCyp).

Provided by:
Vrije Universiteit Amsterdam
Type:
Application, Software, Processing tool, Trained model, Service
Applicability domain:
Predictive toxicology, Computational modelling, Bioinformatics
Topic:
Structure-activity relationship (SAR / QSAR)
For end-users
For developers
More →

News & events

Implementation Challenge

The implementation challenge provided financial support to associated partners, which are working on integrating their services into OpenRiskNet.

The winners of the challenge are announced on the dedicated page.

Introduction and demo virtual meetings

A series of introduction and demo virtual meetings were organised by the consortium. The video recordings of these webinars and the presentation slides are available in the OpenRiskNet library. The complete list events are announced on the website.

Meet us

Meet us in person at one of these upcoming conferences and other events. Details on the past events and the resources generated are also available.

A final workshop was organised on 23-24 October 2019 (Amsterdam, The Netherlands). The details on the topics, program and materials are available on the event web page or in the workshop report.