Identification and linking of data related to AOPWiki (an OpenRiskNet case study)
Tuesday, 26 March 2019, 17:00 CET
Presenters: Marvin Martens and Egon Willighagen (Department of Bioinformatics, Maastricht University, The Netherlands), Thomas Exner (Edelweiss Connect GmbH, Switzerland)
This webinar will provide an introduction to the OpenRiskNet project and its case studies that are used to test and evaluate methods, workflows, and solutions for the predictive toxicology and risk assessment community.
One of these case studies is AOPLink, managed by Maastricht University, which aims for the validation and linking of existing knowledge to support Adverse Outcome Pathways (AOPs). The case study involves the establishment of links between AOPs and experimental data, chemical databases, and the molecular pathway database WikiPathways. In order to do that, a FAIR version of AOP-Wiki (the main AOP resource) and WikiPathways are to be created, and by utilizing RDF, they will be implemented in workflows. These workflows can be used, for example, to look up data for an AOP to support the biological plausibility, find AOPs related to experimental results, or identify the molecular pathways underlying the AOPs.
Resources & Training materials
BridgeDb identifier mapping service
AOP-DB SPARQL Endpoint
AOP-Wiki SPARQL Endpoint